Tpl2 antibody
Splet24. mar. 2024 · TPL2 inhibitor (GS-5290) Inflammatory bowel disease PHASE 1 IRAK4 inhibitor (GS-5718) Lupus PHASE 1 α4β7 inhibitor (GS-1427) Inflammatory bowel disease … SpletHere, we show multitier posttranscriptional control of TPL2 protein levels by p38γ/p38δ, independent of their kinase activity. p38γ/p38δ stabilizes TPL2 protein by direct …
Tpl2 antibody
Did you know?
SpletTPL2 Polyclonal Antibody, Invitrogen™-Rabbit Polyclonal Antibody Shop TPL2 Polyclonal Antibody, Invitrogen™ at Fishersci.fi
Splet18. mar. 2014 · Tpl2 regulates various inflammatory pathways by activating the ERK mediated MAP kinase pathway in innate immune cells such as macrophages and dendritic cells. In this study, we found that a specific small molecule Tpl2 inhibitor blocked IFN-γ and TNF-α secretion as well as cytolytic activity of human CTLs. Splet23. jun. 2024 · Inhibition of TPL2 blocked both MAPK and NF-κB signaling, and suppressed KRAS -mutant cell growth. To counter chemotherapy-induced genotoxic stress, PDAC …
Splet06. okt. 2009 · Tpl2 inhibitor acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 with an IC 50 of 50 nmol/l. It displays significant selectivity over other related kinases such as EGF receptor, MEK, mitogen-activated protein kinase–activated protein kinase-2 (MK2), p38, Src, and protein kinase C. Splet21. apr. 2024 · Tpl2 D270A kinase-dead mutation reduced the phosphorylation of several proteins linked to endocytosis, ... However, uptake of latex beads by BMDMs did not …
Splet描述了降解剂‑抗体缀合物(DAC)，该降解剂‑抗体缀合物包含抗TM4SF1抗体及其抗原结合片段。所述的降解剂分子包含泛素E3连接 ...
Splet15. jan. 2008 · Activation of the TPL2-MKK1/2-ERK1/2 signalling pathway is essential for lipopolysaccharide (LPS)-stimulated production of TNFα in macrophages. Here, we … symbyax medicaidSpletTpl2 (tumor progression locus 2), also known as COT (cancer osaka thyroid), is a serine/threonine kinase expressed primarily in hematopoietic tissues, lung and liver (1). Over-expression of Tpl2 potentiates MAP kinase pathways through MEK1 and SEK1, as … th520Splet20. avg. 2024 · In some experiments, the WT and Tpl2-deficient mice were intravenously injected with 200 μg anti-Ly6G antibody for 3 times to deplete MDSC in vivo, or the Rag1 … symbyx light therapySpletIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 µm post-manufacturing filtered. Target Information CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. th-520h-ot-bl-m-hgSpletFurther studies explained how Tpl2 inhibition protects from antibody-induced thrombocytopenia, by showing that Tpl2 is activated by FcγR signals in macrophages … symbyax for bipolar depressionhttp://www.jinpanmed.cn/archives/date/2024/04/14/page/2 th 51 westminsterSpletTested Applications: Western. Mouse polyclonal TBL2 antibody. 100% Bioguaranteed th5220d1029 honeywell thermostat